We have cloned a novel member of the mouse protein phosphatase 2C family, PP2Cη. Sequence analysis suggests that PP2Cη, PP2Cζ and NERPP-2C constitute a unique subgroup of the PP2C family. PP2Cη had extremely low activity against α-casein compared with PP2Cα and was localized mainly in cell nuclei, suggesting that PP2Cη dephosphorylates a unique nuclear protein(s) in the cells.
|Number of pages||8|
|Journal||Biochimica et Biophysica Acta - Gene Structure and Expression|
|Publication status||Published - 2003 Nov 30|
- Enzyme activity
- Protein phosphatase 2C
- Subcellular localization