Molecular evolutionary analysis of yeast protein interaction network

Soichi Ogishima, Takeshi Hase, So Nakagawa, Yasuhiro Suzuki, Hiroshi Tanaka

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


To understand life as biological system, evolutionary understanding is indispensable. Protein interactions data are rapidly accumulating and are suitable for system-level evolutionary analysis. We have analyzed yeast protein interaction network by both mathematical and biological approaches. In this poster presentation, we inferred the evolutionary birth periods of yeast proteins by reconstructing phylogenetic profile. It has been thought that hub proteins that have high connection degree are evolutionary old. But our analysis showed that hub proteins are entirely evolutionary new. We also examined evolutionary processes of protein complexes. It showed that member proteins of complexes were tend to have appeared in the same evolutionary period. Our results suggested that protein interaction network evolved by modules that form the functional unit. We also reconstructed standardized phylogenetic trees and calculated evolutionary rates of yeast proteins. It showed that there is no obvious correlation between evolutionary rates and connection degrees of yeast proteins. COPYRIGHT

Original languageEnglish
Title of host publicationProceedings - Wec 05
Subtitle of host publicationFourth World Enformatika Conference
EditorsC. Ardil
Number of pages4
Publication statusPublished - 2005
EventWec 05: Fourth World Enformatika Conference - Istanbul, Turkey
Duration: 2005 Jun 242005 Jun 26

Publication series

NameProceedings - Wec 05: Fourth World Enformatika Conference


ConferenceWec 05: Fourth World Enformatika Conference


  • Connection degrees
  • Evolution
  • Evolutionary rate
  • Modularity
  • Protein interaction network


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