Abstract
Odontogenic tumors are lesions derived from the elements of the tooth-forming apparatus and are found exclusively within the jawbones. This review represents a contemporary outline of our current understanding of the molecular and genetic alterations associated with the development and progression of odontogenic tumors, including oncogenes, tumor-suppressor genes, oncoviruses, growth factors, telomerase, cell cycle regulators, apoptosis-related factors, regulators of tooth development, hard tissue-related proteins, cell adhesion molecules, matrix-degrading proteinases, angiogenic factors, and osteolytic cytokines. It is hoped that better understanding of related molecular mechanisms will help to predict the course of odontogenic tumors and lead to the development of new therapeutic concepts for their management.
| Original language | English |
|---|---|
| Pages (from-to) | 65-74 |
| Number of pages | 10 |
| Journal | Journal of Oral Pathology and Medicine |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2006 Feb 1 |
Keywords
- Molecular alteration
- Odontogenic tumor
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Oral Surgery
- Otorhinolaryngology
- Cancer Research
- Periodontics
