Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using quartz crystal microbalance

Song Yan Han; Dong Bo Liu; Liang Huang; Shen Qi Wang; Qing Ping Liu; Junichi Anzai; Osa Tetsuo; Qiang Chen

Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using quartz crystal microbalance

Song Yan Han, Dong Bo Liu, Liang Huang, Shen Qi Wang, Qing Ping Liu, Junichi Anzai, Osa Tetsuo, Qiang Chen

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

Abstract

The use of quartz crystal microbalance (QCM) for monitoring in situ the adsorption of low-density lipoprotein (LDL) onto cholesterol modified dextran (CMD) was described. The kinetic studies were made. The experimental results show that kinetic curves are fitted for that of Langmuir adsorption equation quite well, when LDL mass concentration (ng/μL) are 9.9, 12.38, 14.14, respectively, and the rate constants for adsorption (mol·L^-1·s^-1) and adsorption capacity (ng/cm²) are estimated to be 0.0477, 0.0536, 0.0628 and 107.6, 139.6, 167.9, respectively. The maximal LDL adsorption capacity attains 284.8 ng/cm² and the adsorptive efficiency was calculated as 72.91%.

Original language	English
Pages (from-to)	1166-1169
Number of pages	4
Journal	Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities
Volume	26
Issue number	6
Publication status	Published - 2005 Jun 1

Keywords

Adsorption
Cholesterol modified dextran
Low-density lipoprotein
Quartz crystal microbalance

ASJC Scopus subject areas

Chemistry(all)

Cite this

Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using quartz crystal microbalance. / Han, Song Yan; Liu, Dong Bo; Huang, Liang et al.

In: Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities, Vol. 26, No. 6, 01.06.2005, p. 1166-1169.

Research output: Contribution to journal › Article › peer-review

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title = "Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using quartz crystal microbalance",

abstract = "The use of quartz crystal microbalance (QCM) for monitoring in situ the adsorption of low-density lipoprotein (LDL) onto cholesterol modified dextran (CMD) was described. The kinetic studies were made. The experimental results show that kinetic curves are fitted for that of Langmuir adsorption equation quite well, when LDL mass concentration (ng/μL) are 9.9, 12.38, 14.14, respectively, and the rate constants for adsorption (mol·L-1·s-1) and adsorption capacity (ng/cm2) are estimated to be 0.0477, 0.0536, 0.0628 and 107.6, 139.6, 167.9, respectively. The maximal LDL adsorption capacity attains 284.8 ng/cm2 and the adsorptive efficiency was calculated as 72.91%.",

keywords = "Adsorption, Cholesterol modified dextran, Low-density lipoprotein, Quartz crystal microbalance",

author = "Han, {Song Yan} and Liu, {Dong Bo} and Liang Huang and Wang, {Shen Qi} and Liu, {Qing Ping} and Junichi Anzai and Osa Tetsuo and Qiang Chen",

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T1 - Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using quartz crystal microbalance

AU - Han, Song Yan

AU - Liu, Dong Bo

AU - Huang, Liang

AU - Wang, Shen Qi

AU - Liu, Qing Ping

AU - Anzai, Junichi

AU - Tetsuo, Osa

AU - Chen, Qiang

PY - 2005/6/1

Y1 - 2005/6/1

N2 - The use of quartz crystal microbalance (QCM) for monitoring in situ the adsorption of low-density lipoprotein (LDL) onto cholesterol modified dextran (CMD) was described. The kinetic studies were made. The experimental results show that kinetic curves are fitted for that of Langmuir adsorption equation quite well, when LDL mass concentration (ng/μL) are 9.9, 12.38, 14.14, respectively, and the rate constants for adsorption (mol·L-1·s-1) and adsorption capacity (ng/cm2) are estimated to be 0.0477, 0.0536, 0.0628 and 107.6, 139.6, 167.9, respectively. The maximal LDL adsorption capacity attains 284.8 ng/cm2 and the adsorptive efficiency was calculated as 72.91%.

AB - The use of quartz crystal microbalance (QCM) for monitoring in situ the adsorption of low-density lipoprotein (LDL) onto cholesterol modified dextran (CMD) was described. The kinetic studies were made. The experimental results show that kinetic curves are fitted for that of Langmuir adsorption equation quite well, when LDL mass concentration (ng/μL) are 9.9, 12.38, 14.14, respectively, and the rate constants for adsorption (mol·L-1·s-1) and adsorption capacity (ng/cm2) are estimated to be 0.0477, 0.0536, 0.0628 and 107.6, 139.6, 167.9, respectively. The maximal LDL adsorption capacity attains 284.8 ng/cm2 and the adsorptive efficiency was calculated as 72.91%.

KW - Adsorption

KW - Cholesterol modified dextran

KW - Low-density lipoprotein

KW - Quartz crystal microbalance

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JO - Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities

JF - Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities

IS - 6

ER -

Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using quartz crystal microbalance

Abstract

Keywords

ASJC Scopus subject areas

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