TY - JOUR
T1 - MoS2@C nanosphere as near infrared / pH dual response platform for chemical photothermal combination treatment
AU - Zhang, Xiao
AU - Zhao, Zhihuan
AU - Yang, Pengfei
AU - Liu, Wen
AU - Fan, Jimin
AU - Zhang, Bing
AU - Yin, Shu
N1 - Funding Information:
This work was partly supported by the National Natural Science Foundation of China ( 21605111 ); Nature Science Foundation of Shanxi ( 2016011079 ); JSPS KAKENHI ( JP16H06439 , Grant-in-Aid for Scientific Research on Innovative Areas).
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/8
Y1 - 2020/8
N2 - The three-dimensional urchin-like MoS2@C nanocomposite was successfully synthesized via one-step hydrothermal synthesis approach. The as-prepared MoS2@C nanoparticles exhibits strong absorb, high photothermal conversion ability (40.8 %), superb biocompatibility and high drug loading capacity for doxorubicin (52.34 %). In vitro drug release experiments show a pH, temperature and near infrared laser-triggered doxorubicinhydro release profile that enhances therapeutic anticancer effects. The drug release curve increased step by step under laser irradiation, and the accumulative delivery amount reached to 64.59 %, which was about 2 times of that without laser irradiation. By using DOX-loaded nano-platform, effective synergistic photothermal therapy for cancer can be achieved and has been systematically verified in vitro. Cell viability experiments showed that the survival rate of cells with MoS2 @C-DOX was only 25.8 %. Therefore, this work presents carbon-based nanoparticles with significant characteristics and is used as a highly potential therapeutic nano-platform for cancer treatment.
AB - The three-dimensional urchin-like MoS2@C nanocomposite was successfully synthesized via one-step hydrothermal synthesis approach. The as-prepared MoS2@C nanoparticles exhibits strong absorb, high photothermal conversion ability (40.8 %), superb biocompatibility and high drug loading capacity for doxorubicin (52.34 %). In vitro drug release experiments show a pH, temperature and near infrared laser-triggered doxorubicinhydro release profile that enhances therapeutic anticancer effects. The drug release curve increased step by step under laser irradiation, and the accumulative delivery amount reached to 64.59 %, which was about 2 times of that without laser irradiation. By using DOX-loaded nano-platform, effective synergistic photothermal therapy for cancer can be achieved and has been systematically verified in vitro. Cell viability experiments showed that the survival rate of cells with MoS2 @C-DOX was only 25.8 %. Therefore, this work presents carbon-based nanoparticles with significant characteristics and is used as a highly potential therapeutic nano-platform for cancer treatment.
KW - Carbon sphere
KW - Chemotherapy
KW - MoS@C-DOX
KW - Photothermal therapy
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U2 - 10.1016/j.colsurfb.2020.111054
DO - 10.1016/j.colsurfb.2020.111054
M3 - Article
AN - SCOPUS:85083584746
SN - 0927-7765
VL - 192
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
M1 - 111054
ER -
