Abstract
The mucosal immune system forms a unique barrier system that handles a myriad of infectious and food antigens exposed to the mucosal surface, in order to prevent their invading into the tissue and producing an excessive immune response. The mucosal immune system interacts with the neuro-endocrine system through hormones in the hypothalamic-pituitary-adrenalaxis and cytokines and with energy metabolism through leptin and its receptor by the mutual expression of receptors and mutual usage of mediators. Thus, it plays an important role for the homeostasis of various gastrointestinal functions and immunologic and metabolic changes.
| Original language | English |
|---|---|
| Pages (from-to) | 17-26 |
| Number of pages | 10 |
| Journal | Biotherapy |
| Volume | 18 |
| Issue number | 1 |
| Publication status | Published - 2004 Jan |
| Externally published | Yes |
Keywords
- Gut-associated lymphoid tissue
- Hypothalamic-pituitary-adrenal axis
- Leptin
- Mucosal barrier
- Mucosal immune system
- Secretory IgA
ASJC Scopus subject areas
- Oncology
- Cancer Research
