Multicenter Prospective Study of Color Doppler Ultrasound for Breast Masses: Utility of Our Color Doppler Method

Takanori Watanabe; Setsuko Kaoku; Takuhiro Yamaguchi; Ayumi Izumori; Sachiyo Konno; Toshitaka Okuno; Hiroko Tsunoda; Kanako Ban; Koichi Hirokaga; Terumasa Sawada; Toshikazu Ito; Shuichi Nakatani; Hidemitsu Yasuda; Masahiko Tsuruoka; Ei Ueno; Eriko Tohno; Takeshi Umemoto; Takako Shirakawa

doi:10.1016/j.ultrasmedbio.2019.01.021

Multicenter Prospective Study of Color Doppler Ultrasound for Breast Masses: Utility of Our Color Doppler Method

Takanori Watanabe, Setsuko Kaoku, Takuhiro Yamaguchi, Ayumi Izumori, Sachiyo Konno, Toshitaka Okuno, Hiroko Tsunoda, Kanako Ban, Koichi Hirokaga, Terumasa Sawada, Toshikazu Ito, Shuichi Nakatani, Hidemitsu Yasuda, Masahiko Tsuruoka, Ei Ueno, Eriko Tohno, Takeshi Umemoto, Takako Shirakawa

MED - Public Health

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The use of color Doppler ultrasound (CD)for distinguishing between benign and malignant breast lesions remains controversial. This study (JABTS BC-04 study)was aimed at confirming the usefulness of our CD diagnostic criteria. We evaluated ultrasound images of 1408 solid breast masses from 16 institutions in Japan (malignant: 839, benign: 569). Multivariate analysis indicated that vascularity (amount of blood flow), vascular flow pattern (“surrounding marginal flow” or “penetrating flow”)and the incident angle of penetrating flow were significant findings for distinguishing between benign and malignant lesions. However, the sensitivity and specificity of B-mode alone did not improve significantly with CD addition (97.6% → 97.9%, 38.3% → 41.5%, respectively). We explored the causes of these negative results and found that age should have been considered when evaluating vascularity. Simulation experiments suggested that specificity is significantly improved when age is taken into consideration (38.3% → 46.0%, p < 0.001)and we thereby improved our diagnostic criteria.

Original language	English
Pages (from-to)	1367-1379
Number of pages	13
Journal	Ultrasound in Medicine and Biology
Volume	45
Issue number	6
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2019.01.021
Publication status	Published - 2019 Jun

Keywords

Breast cancer
Color Doppler
Diagnostic criteria
Elastography
Multicenter study
Ultrasound

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ultrasmedbio.2019.01.021

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Watanabe, T., Kaoku, S., Yamaguchi, T., Izumori, A., Konno, S., Okuno, T., Tsunoda, H., Ban, K., Hirokaga, K., Sawada, T., Ito, T., Nakatani, S., Yasuda, H., Tsuruoka, M., Ueno, E., Tohno, E., Umemoto, T., & Shirakawa, T. (2019). Multicenter Prospective Study of Color Doppler Ultrasound for Breast Masses: Utility of Our Color Doppler Method. Ultrasound in Medicine and Biology, 45(6), 1367-1379. https://doi.org/10.1016/j.ultrasmedbio.2019.01.021

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title = "Multicenter Prospective Study of Color Doppler Ultrasound for Breast Masses: Utility of Our Color Doppler Method",

abstract = "The use of color Doppler ultrasound (CD)for distinguishing between benign and malignant breast lesions remains controversial. This study (JABTS BC-04 study)was aimed at confirming the usefulness of our CD diagnostic criteria. We evaluated ultrasound images of 1408 solid breast masses from 16 institutions in Japan (malignant: 839, benign: 569). Multivariate analysis indicated that vascularity (amount of blood flow), vascular flow pattern (“surrounding marginal flow” or “penetrating flow”)and the incident angle of penetrating flow were significant findings for distinguishing between benign and malignant lesions. However, the sensitivity and specificity of B-mode alone did not improve significantly with CD addition (97.6% → 97.9%, 38.3% → 41.5%, respectively). We explored the causes of these negative results and found that age should have been considered when evaluating vascularity. Simulation experiments suggested that specificity is significantly improved when age is taken into consideration (38.3% → 46.0%, p < 0.001)and we thereby improved our diagnostic criteria.",

keywords = "Breast cancer, Color Doppler, Diagnostic criteria, Elastography, Multicenter study, Ultrasound",

author = "Takanori Watanabe and Setsuko Kaoku and Takuhiro Yamaguchi and Ayumi Izumori and Sachiyo Konno and Toshitaka Okuno and Hiroko Tsunoda and Kanako Ban and Koichi Hirokaga and Terumasa Sawada and Toshikazu Ito and Shuichi Nakatani and Hidemitsu Yasuda and Masahiko Tsuruoka and Ei Ueno and Eriko Tohno and Takeshi Umemoto and Takako Shirakawa",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = jun,

doi = "10.1016/j.ultrasmedbio.2019.01.021",

language = "English",

volume = "45",

pages = "1367--1379",

journal = "Ultrasound in Medicine and Biology",

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Watanabe, T, Kaoku, S, Yamaguchi, T, Izumori, A, Konno, S, Okuno, T, Tsunoda, H, Ban, K, Hirokaga, K, Sawada, T, Ito, T, Nakatani, S, Yasuda, H, Tsuruoka, M, Ueno, E, Tohno, E, Umemoto, T & Shirakawa, T 2019, 'Multicenter Prospective Study of Color Doppler Ultrasound for Breast Masses: Utility of Our Color Doppler Method', Ultrasound in Medicine and Biology, vol. 45, no. 6, pp. 1367-1379. https://doi.org/10.1016/j.ultrasmedbio.2019.01.021

TY - JOUR

T1 - Multicenter Prospective Study of Color Doppler Ultrasound for Breast Masses

T2 - Utility of Our Color Doppler Method

AU - Watanabe, Takanori

AU - Kaoku, Setsuko

AU - Yamaguchi, Takuhiro

AU - Izumori, Ayumi

AU - Konno, Sachiyo

AU - Okuno, Toshitaka

AU - Tsunoda, Hiroko

AU - Ban, Kanako

AU - Hirokaga, Koichi

AU - Sawada, Terumasa

AU - Ito, Toshikazu

AU - Nakatani, Shuichi

AU - Yasuda, Hidemitsu

AU - Tsuruoka, Masahiko

AU - Ueno, Ei

AU - Tohno, Eriko

AU - Umemoto, Takeshi

AU - Shirakawa, Takako

PY - 2019/6

Y1 - 2019/6

N2 - The use of color Doppler ultrasound (CD)for distinguishing between benign and malignant breast lesions remains controversial. This study (JABTS BC-04 study)was aimed at confirming the usefulness of our CD diagnostic criteria. We evaluated ultrasound images of 1408 solid breast masses from 16 institutions in Japan (malignant: 839, benign: 569). Multivariate analysis indicated that vascularity (amount of blood flow), vascular flow pattern (“surrounding marginal flow” or “penetrating flow”)and the incident angle of penetrating flow were significant findings for distinguishing between benign and malignant lesions. However, the sensitivity and specificity of B-mode alone did not improve significantly with CD addition (97.6% → 97.9%, 38.3% → 41.5%, respectively). We explored the causes of these negative results and found that age should have been considered when evaluating vascularity. Simulation experiments suggested that specificity is significantly improved when age is taken into consideration (38.3% → 46.0%, p < 0.001)and we thereby improved our diagnostic criteria.

AB - The use of color Doppler ultrasound (CD)for distinguishing between benign and malignant breast lesions remains controversial. This study (JABTS BC-04 study)was aimed at confirming the usefulness of our CD diagnostic criteria. We evaluated ultrasound images of 1408 solid breast masses from 16 institutions in Japan (malignant: 839, benign: 569). Multivariate analysis indicated that vascularity (amount of blood flow), vascular flow pattern (“surrounding marginal flow” or “penetrating flow”)and the incident angle of penetrating flow were significant findings for distinguishing between benign and malignant lesions. However, the sensitivity and specificity of B-mode alone did not improve significantly with CD addition (97.6% → 97.9%, 38.3% → 41.5%, respectively). We explored the causes of these negative results and found that age should have been considered when evaluating vascularity. Simulation experiments suggested that specificity is significantly improved when age is taken into consideration (38.3% → 46.0%, p < 0.001)and we thereby improved our diagnostic criteria.

KW - Breast cancer

KW - Color Doppler

KW - Diagnostic criteria

KW - Elastography

KW - Multicenter study

KW - Ultrasound

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UR - http://www.scopus.com/inward/citedby.url?scp=85063113845&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2019.01.021

DO - 10.1016/j.ultrasmedbio.2019.01.021

M3 - Article

C2 - 30905536

AN - SCOPUS:85063113845

SN - 0301-5629

VL - 45

SP - 1367

EP - 1379

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 6

ER -

Multicenter Prospective Study of Color Doppler Ultrasound for Breast Masses: Utility of Our Color Doppler Method

Abstract

Keywords

UN SDGs

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