Multicenter randomized trial of postoperative corticosteroid therapy for biliary atresia

Masaki Nio, Toshihiro Muraji

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Purpose: We aimed to evaluate early response to two different corticosteroids doses after Kasai portoenterostomy for biliary atresia (BA). Methods: A prospective, randomized trial was performed in infants from the nationwide BA registry with type 3 BA. Sixty-nine infants were randomized to receive either 4 mg/kg/day (group A, n = 35) or 2 mg/kg/day prednisolone (group B, n = 34). The corticosteroids were started on postoperative day 7, and the dose was tapered toward day 30. Results of liver function tests on days 31 and 60 were compared between the groups. Results: Mean bilirubin, AST, ALT, and GGT levels did not significantly differ between the groups. However, the levels of total and direct bilirubin of infants <70 days old at surgery significantly differed between the groups. Four patients from group A and five from group B, dropped out of the study. Complications during the first month after PE were comparable between the groups. Conclusions: An initial 4 mg/kg/day dose did not significantly improve liver function, except that bilirubin levels were lower in the subgroup of infants <70 days old at surgery. There were no significant complications with either dose of corticosteroids.

Original languageEnglish
Pages (from-to)1091-1095
Number of pages5
JournalPediatric Surgery International
Issue number11
Publication statusPublished - 2013 Nov


  • Biliary atresia
  • CMV infection
  • Corticosteroid
  • Prospective randomized trial

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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