Multicentric osteosarcoma with long-term survival

Toshiaki Aizawa, Kyoji Okada, Eiji Abe, Satoko Tsuchida, Yoichi Shimada, Eiji Itoi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We present a 14-year-old girl with multicentric osteosarcoma who has survived for over 9 years to date. The patient first noticed right knee pain in 1992. Radiographs showed a destructive and sclerotic lesion of the right distal femur. Similar small sclerotic lesions were seen in the proximal metaphysis of the right femur, proximal site of the right humerus, and mid-posterior of the left humerus. A diagnosis of multicentric osteosarcoma was made on a biopsy of the right distal femur. The sclerotic lesions of the bilateral humeri disappeared after systemic chemotherapy (T-20), and thus wide excisions of the right distal femur and proximal femur were performed in 1993. New lesions appeared in the left iliac bone and the first lumbar vertebra on bone scintigraphy 24 months after the first surgery. Chemotherapy and wide excisions of the left iliac bone and the first lumbar vertebra were performed. The patient was well at the latest follow-up in April 2003, with no evidence of local recurrence or distant metastasis, but recently renal dysfunction appeared.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalSkeletal Radiology
Issue number1
Publication statusPublished - 2004 Jan 1
Externally publishedYes


  • CT
  • Chemotherapy
  • Multicentric osteosarcoma
  • Operation
  • Radiographs
  • Renal dysfunction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Multicentric osteosarcoma with long-term survival'. Together they form a unique fingerprint.

Cite this