Multifunctional core-shell silica nanoparticles for highly sensitive 19F magnetic resonance imaging

Hisashi Matsushita, Shin Mizukami, Fuminori Sugihara, Yosuke Nakanishi, Yoshichika Yoshioka, Kazuya Kikuchi

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


19F magnetic resonance imaging (19F MRI) is useful for monitoring particular signals from biological samples, cells, and target tissues, because background signals are missing in animal bodies. Therefore, highly sensitive 19F MRI contrast agents are in great demand for their practical applications. However, we have faced the following challenges: 1) increasing the number of fluorine atoms decreases the solubility of the molecular probes, and 2) the restriction of the molecular mobility attenuates the 19F MRI signals. Herein, we developed novel multifunctional core-shell nanoparticles to solve these issues. They are composed of a core micelle filled with liquid perfluorocarbon and a robust silica shell. These core-shell nanoparticles have superior properties such as high sensitivity, modifiability of the surface, biocompatibility, and sufficient in vivo stability. By the adequate surface modifications, gene expression in living cells and tumor tissue in living mice were successfully detected by 19F MRI. Highly sensitive 19F magnetic resonance imaging (MRI) is a useful method for in vivo imaging without background signals. However, the low sensitivity of 19F MRI limits its practical application. Novel multifunctional nanoparticles for highly sensitive 19F MRI are reported, which consist of a liquid perfluorocarbon core and a silica shell (see picture).

Original languageEnglish
Pages (from-to)1008-1011
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number4
Publication statusPublished - 2014 Jan 20
Externally publishedYes


  • fluorine
  • imaging agents
  • magnetic resonance imaging
  • nanoparticles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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