TY - JOUR
T1 - Multiobjective design optimization of stent geometry with wall deformation for triangular and rectangular struts
AU - Putra, Narendra Kurnia
AU - Palar, Pramudita Satria
AU - Anzai, Hitomi
AU - Shimoyama, Koji
AU - Ohta, Makoto
N1 - Funding Information:
Funding information This research is supported by Indonesia Endowment for Education Fund (LPDP), Ministry of Finance, Republic of Indonesia through Beasiswa Pendidikan Indonesia Scholarship Program for Doctorate Students and the ImPACT program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan).
Publisher Copyright:
© 2018, International Federation for Medical and Biological Engineering.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The stent geometrical design (e.g., inter-strut gap, length, and strut cross-section) is responsible for stent–vessel contact problems and changes in the blood flow. These changes are crucial for causing some intravascular abnormalities such as vessel wall injury and restenosis. Therefore, structural optimization of stent design is necessary to find the optimal stent geometry design. In this study, we performed a multiobjective stent optimization for minimization of average stress and low wall shear stress ratio while considering the wall deformation in 3D flow simulations of triangular and rectangular struts. Surrogate-based optimization with Kriging method and expected hypervolume improvement (EHVI) are performed to construct the surrogate model map and find the best configuration of inter-strut gap (G) and side length (SL). In light of the results, G-SL configurations of 2.81–0.39 and 3.00–0.43 mm are suggested as the best configuration for rectangular and triangular struts, respectively. Moreover, considering the surrogate model and flow pattern conditions, we concluded that triangular struts work better to improve the intravascular hemodynamics. [Figure not available: see fulltext.].
AB - The stent geometrical design (e.g., inter-strut gap, length, and strut cross-section) is responsible for stent–vessel contact problems and changes in the blood flow. These changes are crucial for causing some intravascular abnormalities such as vessel wall injury and restenosis. Therefore, structural optimization of stent design is necessary to find the optimal stent geometry design. In this study, we performed a multiobjective stent optimization for minimization of average stress and low wall shear stress ratio while considering the wall deformation in 3D flow simulations of triangular and rectangular struts. Surrogate-based optimization with Kriging method and expected hypervolume improvement (EHVI) are performed to construct the surrogate model map and find the best configuration of inter-strut gap (G) and side length (SL). In light of the results, G-SL configurations of 2.81–0.39 and 3.00–0.43 mm are suggested as the best configuration for rectangular and triangular struts, respectively. Moreover, considering the surrogate model and flow pattern conditions, we concluded that triangular struts work better to improve the intravascular hemodynamics. [Figure not available: see fulltext.].
KW - Computational simulation
KW - Kriging surrogate method
KW - Multiobjective optimization
KW - Restenosis
KW - Stent
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U2 - 10.1007/s11517-018-1864-6
DO - 10.1007/s11517-018-1864-6
M3 - Article
AN - SCOPUS:85049562069
SN - 0140-0118
VL - 57
SP - 15
EP - 26
JO - Medical and Biological Engineering and Computing
JF - Medical and Biological Engineering and Computing
IS - 1
ER -