TY - JOUR
T1 - Multistage regulation of Th1-type immune responses by the transcription factor IRF-1
AU - Taki, Shinsuke
AU - Sato, Takeo
AU - Ogasawara, Kouetsu
AU - Fukuda, Taeko
AU - Sato, Mitsuharu
AU - Hida, Shigeaki
AU - Suzuki, Gen
AU - Mitsuyama, Masao
AU - Shin, Eun Hee
AU - Kojima, Soumei
AU - Taniguchi, Tadatsugu
AU - Asano, Yoshihiro
N1 - Funding Information:
We thank Dr. Hiroshi Yamamoto, Dr. Hiromi Fujiwara, Dr. Dennis Loh, and the Genetic Institute for the IL-12p40 probe, anti-CD8 monoclonal antibody, DO11.10 TCR tg mice, and recombinant mouse IL-12, respectively. Helpful discussion and critical comments provided by Dr. Marc S. Lamphier, Dr. Roger Perlmutter, and Dr. Nobuyuki Tanaka and help provided by S. Matsumoto are also acknowledged. This work was supported in part by a special grant for Advanced Research on Cancer from the Ministry of Education, Science and Culture of Japan and by the “Research for the Future” Program of the Japan Society for the Promotion of Science.
PY - 1997/6
Y1 - 1997/6
N2 - Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice tacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4+ T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.
AB - Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice tacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4+ T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.
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U2 - 10.1016/S1074-7613(00)80443-4
DO - 10.1016/S1074-7613(00)80443-4
M3 - Article
C2 - 9208840
AN - SCOPUS:0030741433
SN - 1074-7613
VL - 6
SP - 673
EP - 679
JO - Immunity
JF - Immunity
IS - 6
ER -
