Muramyl dipeptides: prospect for cancer treatments and immunostimulation.

S. Kotani, I. Azuma, Haruhiko Takada, M. Tsujimoto, Y. Yamamura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The immunopharmacological activities of bacterial cell walls and muramyl peptides were collected in table form with a comprehensive literature. The past and present studies emphasizing the host-defense enhancing activities of muramyl peptides for antitumor immunotherapy were surveyed along three possible approaches: 1) the nonspecific enhancement of natural defense ability of host against tumor cells themselves; 2) the enhancement of nonspecific resistance of host to microbial infections which are frequently encountered and difficult to treat in the advanced stage of tumor patients; and 3) the stimulation of immunity against tumor-specific or tumor-associated immunogens. Finally, the prospects of successful antitumor immunotherapy with muramyl peptides and their derivatives was discussed.

Original languageEnglish
Pages (from-to)117-158
Number of pages42
JournalAdvances in experimental medicine and biology
Publication statusPublished - 1983 Dec 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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