Murine chromosomal location of four class iii pou transcription factors

Karen B. Avraham, Brian C. Cho, Debra Gilbert, Hideta Fujii, Koji Okamoto, Takuya Shimazaki, Toshiro Ito, Hiroki Shoji, Yoshio Wakamatsu, Hisato Kondoh, Naoki Takahashi, Masami Muramatsu, Hiroshi Hamada, Neal G. Copeland, Nancy A. Jenkins

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


A family of mouse genes encoding class III POU transcription factors consists of four members: Oct-6, Brn-2, Brn-1, and Brn-4. In accordance with mouse nomenclature, these loci have been designated Otf-6, Otf-7, Otf-8, and Otf-9, respectively. While the four genes share a highly conserved class III POU domain, the remaining regions are considerably diverged from each other. The POU domains of these transcription factors recognize the octamer-motif sequence and possess a similar DNA-binding specificity. Chromosomal mapping has demonstrated that the four genes are unlinked: Otf-6 is located on the distal region of chromosome 4, Otf-7 on the proximal region of chromosome 4, Otf-8 on chromosome 1, and Otf-9 on the X chromosome.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
Issue number1
Publication statusPublished - 1993 Oct


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