Mutations of the p53 gene, including an intronic point mutation, in colorectal tumors

Chikashi Ishioka; Toshiaki Sato; Makio Gamoh; Takao Suzuki; Hiroyuki Shibata; Ryunosuke Kanamaru; Akira Wakui; Tadasu Yamazaki

doi:10.1016/0006-291X(91)90623-F

Mutations of the p53 gene, including an intronic point mutation, in colorectal tumors

Chikashi Ishioka, Toshiaki Sato, Makio Gamoh, Takao Suzuki, Hiroyuki Shibata, Ryunosuke Kanamaru, Akira Wakui, Tadasu Yamazaki

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

In this study, analysis of structural changes of the p53 gene in colorectal tumors revealed point mutations detected in 8 of 14 carcinomas and 2 of 2 adenomas. Of these 10 cases with point mutations, eight had one or more missense mutations, one had a nonsense mutation, and the remaining one had, interestingly, an intronic point mutation with subsequent activation of a cryptic splice donor site in the flanking exon. This report contains the first identification of an intronic point mutation of the p53 gene in a colorectal cancer case.

Original language	English
Pages (from-to)	901-906
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	177
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(91)90623-F
Publication status	Published - 1991 Jun 28

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10.1016/0006-291X(91)90623-F

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title = "Mutations of the p53 gene, including an intronic point mutation, in colorectal tumors",

abstract = "In this study, analysis of structural changes of the p53 gene in colorectal tumors revealed point mutations detected in 8 of 14 carcinomas and 2 of 2 adenomas. Of these 10 cases with point mutations, eight had one or more missense mutations, one had a nonsense mutation, and the remaining one had, interestingly, an intronic point mutation with subsequent activation of a cryptic splice donor site in the flanking exon. This report contains the first identification of an intronic point mutation of the p53 gene in a colorectal cancer case.",

author = "Chikashi Ishioka and Toshiaki Sato and Makio Gamoh and Takao Suzuki and Hiroyuki Shibata and Ryunosuke Kanamaru and Akira Wakui and Tadasu Yamazaki",

note = "Funding Information: ACKNOWLEDGMENTSW: e thank Akira Funada, M.D. for generously providing tissue material. This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education Science and Culture of Japan.",

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T1 - Mutations of the p53 gene, including an intronic point mutation, in colorectal tumors

AU - Ishioka, Chikashi

AU - Sato, Toshiaki

AU - Gamoh, Makio

AU - Suzuki, Takao

AU - Shibata, Hiroyuki

AU - Kanamaru, Ryunosuke

AU - Wakui, Akira

AU - Yamazaki, Tadasu

N1 - Funding Information: ACKNOWLEDGMENTSW: e thank Akira Funada, M.D. for generously providing tissue material. This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education Science and Culture of Japan.

PY - 1991/6/28

Y1 - 1991/6/28

N2 - In this study, analysis of structural changes of the p53 gene in colorectal tumors revealed point mutations detected in 8 of 14 carcinomas and 2 of 2 adenomas. Of these 10 cases with point mutations, eight had one or more missense mutations, one had a nonsense mutation, and the remaining one had, interestingly, an intronic point mutation with subsequent activation of a cryptic splice donor site in the flanking exon. This report contains the first identification of an intronic point mutation of the p53 gene in a colorectal cancer case.

AB - In this study, analysis of structural changes of the p53 gene in colorectal tumors revealed point mutations detected in 8 of 14 carcinomas and 2 of 2 adenomas. Of these 10 cases with point mutations, eight had one or more missense mutations, one had a nonsense mutation, and the remaining one had, interestingly, an intronic point mutation with subsequent activation of a cryptic splice donor site in the flanking exon. This report contains the first identification of an intronic point mutation of the p53 gene in a colorectal cancer case.

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Mutations of the p53 gene, including an intronic point mutation, in colorectal tumors

Abstract

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