Mutual Binding Inhibition of Tetrodotoxin and Saxitoxin to Their Binding Protein from the Plasma of the Puffer Fish, Fugu pardalis

Mari Yotsu-Yamashita; Yuki Shoji; Takahiro Terakawa; Shunichi Yamada; Teruo Miyazawa; Takeshi Yasumoto

doi:10.1271/bbb.66.2520

Mutual Binding Inhibition of Tetrodotoxin and Saxitoxin to Their Binding Protein from the Plasma of the Puffer Fish, Fugu pardalis

Mari Yotsu-Yamashita, Yuki Shoji, Takahiro Terakawa, Shunichi Yamada, Teruo Miyazawa, Takeshi Yasumoto

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The mutual binding inhibition of tetrodotoxin and saxitoxin to their binding protein from the plasma of Fugu pardalis was investigated by HPLC. The values for the half inhibitory concentration of tetrodotoxin (1.6 μM) binding to this protein (1.2 μM) for saxitoxin, and of saxitoxin (0.47 μM) binding to that (0.30 μM) for tetrodotoxin were 0.35±0.057 μM and 81±16 μM (n=2), respectively.

Original language	English
Pages (from-to)	2520-2524
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	66
Issue number	11
DOIs	https://doi.org/10.1271/bbb.66.2520
Publication status	Published - 2002 Jan 1

Keywords

Binding protein
Mutual inhibition
Puffer fish
Saxitoxin
Tetrodotoxin

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abstract = "The mutual binding inhibition of tetrodotoxin and saxitoxin to their binding protein from the plasma of Fugu pardalis was investigated by HPLC. The values for the half inhibitory concentration of tetrodotoxin (1.6 μM) binding to this protein (1.2 μM) for saxitoxin, and of saxitoxin (0.47 μM) binding to that (0.30 μM) for tetrodotoxin were 0.35±0.057 μM and 81±16 μM (n=2), respectively.",

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T1 - Mutual Binding Inhibition of Tetrodotoxin and Saxitoxin to Their Binding Protein from the Plasma of the Puffer Fish, Fugu pardalis

AU - Yotsu-Yamashita, Mari

AU - Shoji, Yuki

AU - Terakawa, Takahiro

AU - Yamada, Shunichi

AU - Miyazawa, Teruo

AU - Yasumoto, Takeshi

PY - 2002/1/1

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N2 - The mutual binding inhibition of tetrodotoxin and saxitoxin to their binding protein from the plasma of Fugu pardalis was investigated by HPLC. The values for the half inhibitory concentration of tetrodotoxin (1.6 μM) binding to this protein (1.2 μM) for saxitoxin, and of saxitoxin (0.47 μM) binding to that (0.30 μM) for tetrodotoxin were 0.35±0.057 μM and 81±16 μM (n=2), respectively.

AB - The mutual binding inhibition of tetrodotoxin and saxitoxin to their binding protein from the plasma of Fugu pardalis was investigated by HPLC. The values for the half inhibitory concentration of tetrodotoxin (1.6 μM) binding to this protein (1.2 μM) for saxitoxin, and of saxitoxin (0.47 μM) binding to that (0.30 μM) for tetrodotoxin were 0.35±0.057 μM and 81±16 μM (n=2), respectively.

KW - Binding protein

KW - Mutual inhibition

KW - Puffer fish

KW - Saxitoxin

KW - Tetrodotoxin

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Mutual Binding Inhibition of Tetrodotoxin and Saxitoxin to Their Binding Protein from the Plasma of the Puffer Fish, Fugu pardalis

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Keywords

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