TY - JOUR
T1 - Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy
AU - Nakamura, Takaaki
AU - Kaneko, Kimihiko
AU - Watanabe, Genya
AU - Harashima, Shogo
AU - Kawasaki, Emiko
AU - Tsukita, Kenichi
AU - Takahashi, Toshiyuki
AU - Nakashima, Ichiro
AU - Misu, Tatsuro
AU - Suzuki, Yasushi
N1 - Funding Information:
The authors thank Prof. Susumu Kusunoki and his colleagues at the Kindai University for measuring the levels of anti-ganglioside antibodies and Dr. Hidenori Ogata, Prof. Junichi Kira, and their colleagues at the Kyushu University for measuring anti-NF155 antibody levels.
Publisher Copyright:
© 2020, Fondazione Società Italiana di Neurologia.
PY - 2021/3
Y1 - 2021/3
N2 - Myelin oligodendrocyte glycoprotein (MOG)-IgG detected by the cell-based assay is associated with demyelinating diseases of the central nervous system, such as optic neuritis, myelitis, and acute disseminated encephalomyelitis, but rarely with peripheral neuropathy. Here, we describe the case of a 32-year-old MOG-IgG+ woman who developed central and peripheral demyelinating lesions. In contrast to previous similar cases, she uniquely presented with repeated subsequent relapses in the peripheral nerve, mimicking chronic inflammatory demyelinating polyneuropathy. Possible pathogenic implications of MOG-IgG in combined central and peripheral nervous system diseases are considered.
AB - Myelin oligodendrocyte glycoprotein (MOG)-IgG detected by the cell-based assay is associated with demyelinating diseases of the central nervous system, such as optic neuritis, myelitis, and acute disseminated encephalomyelitis, but rarely with peripheral neuropathy. Here, we describe the case of a 32-year-old MOG-IgG+ woman who developed central and peripheral demyelinating lesions. In contrast to previous similar cases, she uniquely presented with repeated subsequent relapses in the peripheral nerve, mimicking chronic inflammatory demyelinating polyneuropathy. Possible pathogenic implications of MOG-IgG in combined central and peripheral nervous system diseases are considered.
KW - Combined central and peripheral demyelination
KW - Delivery
KW - Myelin oligodendrocyte glycoprotein
KW - Myelitis
KW - Radiculitis
KW - Relapse
UR - http://www.scopus.com/inward/record.url?scp=85092712163&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85092712163&partnerID=8YFLogxK
U2 - 10.1007/s10072-020-04822-7
DO - 10.1007/s10072-020-04822-7
M3 - Article
C2 - 33078247
AN - SCOPUS:85092712163
SN - 1590-1874
VL - 42
SP - 1135
EP - 1138
JO - Neurological Sciences
JF - Neurological Sciences
IS - 3
ER -
