TY - JOUR
T1 - (N-Methyl-[11C])pyrilamine, a radiotracer for histamine H-1 receptors
T2 - Radiochemical synthesis and biodistribution study in mice
AU - Yanai, Kazuhiko
AU - Dannals, Robert F.
AU - Wilson, Alan A.
AU - Ravert, Hayden T.
AU - Scheffel, Ursula
AU - Tanada, Shuji
AU - Wagner, Henry N.
PY - 1988
Y1 - 1988
N2 - The histamine H-1 receptor antagonist, pyrilamine (N-((4-methoxyphenyl)methyl)-N′,N′-dimethyl-N-2-pyridinyl-1,2-ethanediamine) was labeled with carbon-11 by N-alkylation of desmethylpyrilamine with [11C]iodomethane, and purified by preparative high performance liquid chromatography. The chemically and radiochemically pure labeled pyrilamine was obtained with specific activity of approximately 2500 mCi/μmol (EOS). In vivo distribution studies in mice suggest that the distribution of this compound parallels the known histamine H-1 receptor density in the brain.
AB - The histamine H-1 receptor antagonist, pyrilamine (N-((4-methoxyphenyl)methyl)-N′,N′-dimethyl-N-2-pyridinyl-1,2-ethanediamine) was labeled with carbon-11 by N-alkylation of desmethylpyrilamine with [11C]iodomethane, and purified by preparative high performance liquid chromatography. The chemically and radiochemically pure labeled pyrilamine was obtained with specific activity of approximately 2500 mCi/μmol (EOS). In vivo distribution studies in mice suggest that the distribution of this compound parallels the known histamine H-1 receptor density in the brain.
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U2 - 10.1016/0883-2897(88)90050-5
DO - 10.1016/0883-2897(88)90050-5
M3 - Article
C2 - 3251895
AN - SCOPUS:0024205425
SN - 0969-8051
VL - 15
SP - 605
EP - 610
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
IS - 6
ER -