N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Sträussler syndrome

Tetsuyuki Kitamoto; Tamaki Muramoto; Caroline Hilbich; Konrad Beyreuther; Jun Tateishi

doi:10.1016/0006-8993(91)91306-L

N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Sträussler syndrome

Tetsuyuki Kitamoto, Tamaki Muramoto, Caroline Hilbich, Konrad Beyreuther, Jun Tateishi

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Kuru plaques are one of the pathological hallmarks in Gerstmann-Sträussler syndrome, and are composed of prion protein (PrP). To elucidate whether N-terminal sequence of Prp is related to amygdaloid formation in vivo, we prepared antibody against synthetic N-terminal peptide (anti-PrP-N). Anti-PrP-N immunolabeled kuru plaques positively. Positive reactions were observed in the periphery of large kuru plaque cores, but not in the center. It is therefore postulated that one of the modification of Prp is N-terminal truncation.

Original language	English
Pages (from-to)	319-321
Number of pages	3
Journal	Brain research
Volume	545
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)91306-L
Publication status	Published - 1991 Apr 5
Externally published	Yes

Keywords

Gerstmann-Sträussler syndrome
Kuru plaque
N-Terminal
Prion protein

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)91306-L

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title = "N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Str{\"a}ussler syndrome",

abstract = "Kuru plaques are one of the pathological hallmarks in Gerstmann-Str{\"a}ussler syndrome, and are composed of prion protein (PrP). To elucidate whether N-terminal sequence of Prp is related to amygdaloid formation in vivo, we prepared antibody against synthetic N-terminal peptide (anti-PrP-N). Anti-PrP-N immunolabeled kuru plaques positively. Positive reactions were observed in the periphery of large kuru plaque cores, but not in the center. It is therefore postulated that one of the modification of Prp is N-terminal truncation.",

keywords = "Gerstmann-Str{\"a}ussler syndrome, Kuru plaque, N-Terminal, Prion protein",

author = "Tetsuyuki Kitamoto and Tamaki Muramoto and Caroline Hilbich and Konrad Beyreuther and Jun Tateishi",

note = "Funding Information: We thankK . Hatanakaan dM. Yonedaf or technicaals sistance, and B. Quinn for reviewingm anuscripTt.h is work was supported by grants( 024542450,1 570198f)r om the Ministryo f Education, Sciencea ndC ulture,t heM inistryo f Healtha ndW elfarea, ndthe Sciencea ndT echnologAyg encyJ,a pan. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1991",

month = apr,

day = "5",

doi = "10.1016/0006-8993(91)91306-L",

language = "English",

volume = "545",

pages = "319--321",

journal = "Molecular Brain Research",

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T1 - N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Sträussler syndrome

AU - Kitamoto, Tetsuyuki

AU - Muramoto, Tamaki

AU - Hilbich, Caroline

AU - Beyreuther, Konrad

AU - Tateishi, Jun

N1 - Funding Information: We thankK . Hatanakaan dM. Yonedaf or technicaals sistance, and B. Quinn for reviewingm anuscripTt.h is work was supported by grants( 024542450,1 570198f)r om the Ministryo f Education, Sciencea ndC ulture,t heM inistryo f Healtha ndW elfarea, ndthe Sciencea ndT echnologAyg encyJ,a pan. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1991/4/5

Y1 - 1991/4/5

N2 - Kuru plaques are one of the pathological hallmarks in Gerstmann-Sträussler syndrome, and are composed of prion protein (PrP). To elucidate whether N-terminal sequence of Prp is related to amygdaloid formation in vivo, we prepared antibody against synthetic N-terminal peptide (anti-PrP-N). Anti-PrP-N immunolabeled kuru plaques positively. Positive reactions were observed in the periphery of large kuru plaque cores, but not in the center. It is therefore postulated that one of the modification of Prp is N-terminal truncation.

AB - Kuru plaques are one of the pathological hallmarks in Gerstmann-Sträussler syndrome, and are composed of prion protein (PrP). To elucidate whether N-terminal sequence of Prp is related to amygdaloid formation in vivo, we prepared antibody against synthetic N-terminal peptide (anti-PrP-N). Anti-PrP-N immunolabeled kuru plaques positively. Positive reactions were observed in the periphery of large kuru plaque cores, but not in the center. It is therefore postulated that one of the modification of Prp is N-terminal truncation.

KW - Gerstmann-Sträussler syndrome

KW - Kuru plaque

KW - N-Terminal

KW - Prion protein

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JO - Molecular Brain Research

JF - Molecular Brain Research

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ER -

N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Sträussler syndrome

Abstract

Keywords

ASJC Scopus subject areas

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