NAD+-glycohydrolase from Streptococcus pyogenes shows cyclic ADP-ribose forming activity

Tadahiro Karasawa, Shin Takasawa, Kiyotaka Yamakawa, Hideto Yonekura, Hiroshi Okamoto, Shinichi Nakamura

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


NAD+-glycohydrolase from Streptococcus pyogenes was purified by successive chromatography on CM Sepharose CL-6B, Sephacryl S-200 HR and hydroxyapatite. The purified enzyme possessed synthesis and hydrolysis activities of cyclic ADP-ribose (cADPR), a newly found second messenger for Ca2+ mobilisation, along with cleavage activity of the ribose-nicotinamide bond in NAD+.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalFEMS Microbiology Letters
Issue number2-3
Publication statusPublished - 1995 Aug 1


  • ADP-ribosyl cyclase
  • Cyclic ADP-ribose
  • Cyclic ADP-ribose hydrolase
  • NAD-glycohydrolase
  • Streptococcus pyogenes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics


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