Nasal cavity epithelioid hemangioendothelioma invading the anterior skull base

Shogo Ogita, Toshiki Endo, Kazuhiro Nomura, Takenori Ogawa, Mika Watanabe, Kenjiro Higashi, Yukio Katori, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that frequently occurs in soft tissues. Patients suffer from local recurrence and remote metastasis because of its malignant potential. Here, we present a rare case of EHE that originated from nasal cavity and invaded intracranially through the anterior skull base. Case Description: This is a 27-year-old woman who presented a local physician with intermittent epistaxis and a facial pain around her nose. Preoperative studies demonstrated that the tumor invaded into anterior skull base and the dura matter. Therefore, we performed combined skull base and transnasal surgery, which achieved complete resection of the tumor. Postoperative course of the patient was uneventful. No recurrence or distant metastasis was observed in the patient for 2 years following the radical resection. Conclusions: To date, four cases of EHE in the nasal cavity were reported. This is the frst case in which EHE demonstrated invasive potentials with intracranial extension. Radical surgical resection plays an important role for better management of invasive paranasal EHE.

Original languageEnglish
Article number28
JournalSurgical Neurology International
Issue number1
Publication statusPublished - 2016 Jan 1


  • Anterior skull base
  • Epithelioid hemangioendothelioma
  • Nasal cavity
  • Vascular tumor


Dive into the research topics of 'Nasal cavity epithelioid hemangioendothelioma invading the anterior skull base'. Together they form a unique fingerprint.

Cite this