TY - JOUR
T1 - National Comprehensive Cancer Network Resectability Status for Pancreatic Carcinoma Predicts Overall Survival
AU - Murakami, Yoshiaki
AU - Satoi, Sohei
AU - Sho, Masayuki
AU - Motoi, Fuyuhiko
AU - Matsumoto, Ippei
AU - Kawai, Manabu
AU - Honda, Goro
AU - Uemura, Kenichiro
AU - Yanagimoto, Hiroaki
AU - Shinzeki, Makoto
AU - Kurata, Masanao
AU - Kinoshita, Shoichi
AU - Yamaue, Hiroki
AU - Unno, Michiaki
N1 - Publisher Copyright:
© 2015 Société Internationale de Chirurgie.
PY - 2015/9/12
Y1 - 2015/9/12
N2 - The aim of this study was to evaluate the validity of preoperative resectability status, as defined by the National Comprehensive Cancer Network (NCCN), from the viewpoint of overall survival. Methods: A total of consecutive 704 patients with pancreatic head carcinoma who underwent pancreatoduodenectomy with upfront surgery at seven Japanese hospitals between 2001 and 2012 were evaluated retrospectively. According to the NCCN definition of preoperative resectability status, tumors were divided into resectable tumors without vascular contact (R group), resectable tumors with portal or superior mesenteric vein (PV/SMV) contact of 蠇180° (R-PV group), borderline resectable(BR) tumors with PV/SMV contact of >180°(BR-PV group), and BR tumors with arterial contact (BR-A group). The relationship between the NCCN definition of preoperative resectability status and overall survival was analyzed. Results: Of the 704 patients, 389, 114, 145, and 56 were classified into the R group, the R-PV group, the BR-PV group, and the BR-A group, respectively. Overall survival of the BR-PV and BR-A groups was significantly worse than that of the R group and R-PV groups (P < 0.05), although there was no significant difference in overall survival between the R group and the R-PV group (P = 0.310). Multivariate analysis revealed that PV/SMV contact of >180°(P = 0.008) and arterial contact (P < 0.001) were independent prognostic factors of overall survival. Conclusion: From the viewpoint of overall survival, the NCCN definition of preoperative resectability status was valid.
AB - The aim of this study was to evaluate the validity of preoperative resectability status, as defined by the National Comprehensive Cancer Network (NCCN), from the viewpoint of overall survival. Methods: A total of consecutive 704 patients with pancreatic head carcinoma who underwent pancreatoduodenectomy with upfront surgery at seven Japanese hospitals between 2001 and 2012 were evaluated retrospectively. According to the NCCN definition of preoperative resectability status, tumors were divided into resectable tumors without vascular contact (R group), resectable tumors with portal or superior mesenteric vein (PV/SMV) contact of 蠇180° (R-PV group), borderline resectable(BR) tumors with PV/SMV contact of >180°(BR-PV group), and BR tumors with arterial contact (BR-A group). The relationship between the NCCN definition of preoperative resectability status and overall survival was analyzed. Results: Of the 704 patients, 389, 114, 145, and 56 were classified into the R group, the R-PV group, the BR-PV group, and the BR-A group, respectively. Overall survival of the BR-PV and BR-A groups was significantly worse than that of the R group and R-PV groups (P < 0.05), although there was no significant difference in overall survival between the R group and the R-PV group (P = 0.310). Multivariate analysis revealed that PV/SMV contact of >180°(P = 0.008) and arterial contact (P < 0.001) were independent prognostic factors of overall survival. Conclusion: From the viewpoint of overall survival, the NCCN definition of preoperative resectability status was valid.
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U2 - 10.1007/s00268-015-3096-3
DO - 10.1007/s00268-015-3096-3
M3 - Article
C2 - 26013206
AN - SCOPUS:84938956589
SN - 0364-2313
VL - 39
SP - 2306
EP - 2314
JO - World Journal of Surgery
JF - World Journal of Surgery
IS - 9
ER -
