TY - JOUR
T1 - Neoadjuvant treatment for resectable pancreatic adenocarcinoma
T2 - What is the best protocol?
AU - Motoi, Fuyuhiko
AU - Unno, Michiaki
N1 - Funding Information:
Conflict of Interest: Author FM and MU received lecture fee from Taiho Pharmaceutical. Author MU was supported by grant from Takeda Pharmaceutical Company.
Publisher Copyright:
© 2020 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterology
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Although upfront surgery has been the gold standard for pancreatic adenocarcinoma that is planned for resection, it should be compared with the alternative strategy of neoadjuvant therapy. Despite the many reports of the efficacy of neoadjuvant therapy, most of them were not comparative. Recently Prep-02/JSAP05 study clearly demonstrated the significant survival benefit of neoadjuvant chemotherapy over upfront surgery for pancreatic adenocarcinoma that is planned for resection. These findings opened a new chapter of neoadjuvant therapy. Ongoing trials are expected to confirm the evidence. This review summarizes the past, present, and future perspectives of neoadjuvant therapy and its optimization.
AB - Although upfront surgery has been the gold standard for pancreatic adenocarcinoma that is planned for resection, it should be compared with the alternative strategy of neoadjuvant therapy. Despite the many reports of the efficacy of neoadjuvant therapy, most of them were not comparative. Recently Prep-02/JSAP05 study clearly demonstrated the significant survival benefit of neoadjuvant chemotherapy over upfront surgery for pancreatic adenocarcinoma that is planned for resection. These findings opened a new chapter of neoadjuvant therapy. Ongoing trials are expected to confirm the evidence. This review summarizes the past, present, and future perspectives of neoadjuvant therapy and its optimization.
KW - neoadjuvant chemotherapy
KW - neoadjuvant therapy
KW - pancreatic adenocarcinoma
KW - resectable pancreatic cancer
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U2 - 10.1002/ags3.12311
DO - 10.1002/ags3.12311
M3 - Review article
AN - SCOPUS:85083537507
SN - 2475-0328
VL - 4
SP - 100
EP - 108
JO - Annals of Gastroenterological Surgery
JF - Annals of Gastroenterological Surgery
IS - 2
ER -
