TY - JOUR
T1 - Neural activity-dependent regulation of gene expression in developing and mature neurons
AU - Abe, Kentaro
PY - 2008/5
Y1 - 2008/5
N2 - Neurons can change their gene expression patterns according to the inputs they have received. This activity-dependent gene regulation mechanism plays an important role in the formation of neural circuits during development. Further, by regulating the synaptic plasticity, this mechanism may function as an essential one for each organism to adapt flexibly to its environment. This review summarizes our current knowledge about the activity-dependent gene regulation mechanism in neurons, focusing on the transcription factors and signaling pathways involved in this mechanism.
AB - Neurons can change their gene expression patterns according to the inputs they have received. This activity-dependent gene regulation mechanism plays an important role in the formation of neural circuits during development. Further, by regulating the synaptic plasticity, this mechanism may function as an essential one for each organism to adapt flexibly to its environment. This review summarizes our current knowledge about the activity-dependent gene regulation mechanism in neurons, focusing on the transcription factors and signaling pathways involved in this mechanism.
KW - Memory
KW - Neural development
KW - Synaptic activity
KW - Synaptic plasticity
KW - Transcription factor
UR - http://www.scopus.com/inward/record.url?scp=41649110546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41649110546&partnerID=8YFLogxK
U2 - 10.1111/j.1440-169X.2008.00999.x
DO - 10.1111/j.1440-169X.2008.00999.x
M3 - Review article
C2 - 18336579
AN - SCOPUS:41649110546
SN - 0012-1592
VL - 50
SP - 261
EP - 271
JO - Development Growth and Differentiation
JF - Development Growth and Differentiation
IS - 4
ER -