Neuroanatomical database of normal Japanese brains

Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Ryuta Kawashima

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


To develop a high-resolution in vivo human neuroanatomy database for Japanese brains, a data set on 1547 normal subjects between the ages of 16 and 79 years has been collected. First, we determined individual reference brains of normal Japanese for each age and gender group. We found there exists cross-generational changes in brain shape, that is, the young generation has a shorter and wider brain than the older generation. Second, we determined the effect of aging on the volume of gray matter and white matter by voxel based morphometry. A significant negative correlation between the gray matter volume and age was observed. We assume that this kind of database is quite useful to investigators who are engaged in basic neuroscience, clinical diagnostics and evaluation of neuropsychiatric disorders in patients.

Original languageEnglish
Pages (from-to)1301-1310
Number of pages10
JournalNeural Networks
Issue number9
Publication statusPublished - 2003 Nov


  • Age related changes
  • Brain
  • Database
  • Gray matter
  • Human
  • Magnetic resonance imaging
  • Reference brain
  • White matter


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