Neuroimaging of cancer patients for psychosocial support and patient care

Manabu Tashiro, Masatoshi Itoh, Kazuo Kubota, Freimut Juengling, Michael Reinhardt, Egbert Nitzsche, Ernst Moser, Kazuhiko Yanai

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Cancer patients often manifest psychological or behavioral problems and their brain functions may not always be normal. The purpose of this paper is to present an overview of the results of a series of studies regarding our examination of regional brain glucose metabolism of cancer patients. Following our preliminary study of Japanese cancer patients and a replication in German patients, we explored the possible underlying mechanism of hypometabolism using positron emission tomography with 18F-fluorodeoxyglucose (FDG PET). An increase in the score of Zung's Self-rating depression scale (SDS) was associated with decreased activity in the prefrontal cortex, anterior cingulate gyrus, and striatura. SDS scores and metabolic activity were negatively correlated especially in the basolateral prefrontal cortex. It seemed that the decreased activity in the prefrontal cortex was specifically associated with depressive mood. Further replications have demonstrated that FDG PET could be used for early detection and prediction of the future onset of psychiatric disorders among cancer patients. Recent advancement of magnetic resonance imaging (MRI) has enabled conductance of sophisticated volumetric analysis. Recent studies suggest that cancer patients with intrusive recollections (one of the key symptoms for diagnosing post-traumatic stress disorder) have significantly smaller amygdala and hippocampus. Thus, functional imaging techniques may be helpful in evaluating mild depression in cancer patients.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalCurrent Medical Imaging Reviews
Issue number1
Publication statusPublished - 2008 Feb


  • Cancer
  • Depression
  • Molecular imaging
  • Positron emission tomography (PET)
  • Regional cerebral glucose metabolism

ASJC Scopus subject areas

  • Internal Medicine
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Neuroimaging of cancer patients for psychosocial support and patient care'. Together they form a unique fingerprint.

Cite this