Neuronal Ca2+-sensitive non-selective cation channels and TRPC5

Research output: Contribution to journalReview articlepeer-review


Membrane excitability is mainly regulated by ion channels, including both voltage-gated and ligand-gated channels. In addition to these conventional types of ion channel, a new class of ionic channel is also involved in regulation of the membrane potential. Transient receptor potential (TRP) channels are expressed not only in excitable cells, such as sensory organs, neurons, and cardiac myocytes, but also in non-excitable cells such as endothelial cells, B lymphocytes, and rat basophilic leukemia mast cells. Most TRP channels are Ca2+-permeable, and some are regulated by intracellular Ca 2+. The aim of this review is to provide an overview of the TRP channel superfamily and describe the electrophysiological properties and physiological roles of the neuronal Ca2+-sensitive non-selective cation channel TRPC5.

Original languageEnglish
Pages (from-to)352-357
Number of pages6
Journaljournal of oral biosciences
Issue number4
Publication statusPublished - 2010


  • Calcium
  • Cation
  • Channel
  • TRP

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dentistry(all)


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