Neuropeptide y inhibits in vivo specific antibody production in rats

Elliot M. Friedman; Michael R. Irwin; Katsonori Nonogaki

doi:10.1006/brbi.1995.1017

Neuropeptide y inhibits in vivo specific antibody production in rats

Elliot M. Friedman, Michael R. Irwin, Katsonori Nonogaki

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The sympathetic neurotransmitter neuropeptide-Y (NPY) is hypothesized to play a role in the in vivo modulation of immune responses. This study examined the effects of intraperitoneal administration of NPY on specific antibody responses to keyhole limper hemocyanin (KLH) in rats. Antibody levels were repeatedly measured by enzyme-linked immunosorbent assay before and after intraperitoneal immunization with KLH. NPY induced a dose-dependent inhibition of ISM and IgG antibody responses following immunization with either physiologic or supraphysiologic doses of antigen. These in vivo results suggests that NPY may be involved in endogenous modulation of immune responses.

Original language	English
Pages (from-to)	182-189
Number of pages	8
Journal	Brain Behavior and Immunity
Volume	9
Issue number	3
DOIs	https://doi.org/10.1006/brbi.1995.1017
Publication status	Published - 1995 Sept
Externally published	Yes

ASJC Scopus subject areas

Immunology
Endocrine and Autonomic Systems
Behavioral Neuroscience

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10.1006/brbi.1995.1017

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AB - The sympathetic neurotransmitter neuropeptide-Y (NPY) is hypothesized to play a role in the in vivo modulation of immune responses. This study examined the effects of intraperitoneal administration of NPY on specific antibody responses to keyhole limper hemocyanin (KLH) in rats. Antibody levels were repeatedly measured by enzyme-linked immunosorbent assay before and after intraperitoneal immunization with KLH. NPY induced a dose-dependent inhibition of ISM and IgG antibody responses following immunization with either physiologic or supraphysiologic doses of antigen. These in vivo results suggests that NPY may be involved in endogenous modulation of immune responses.

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Neuropeptide y inhibits in vivo specific antibody production in rats

Abstract

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