Neuroprotective Therapy: Failure and Future for Clinical Application

Research output: Chapter in Book/Report/Conference proceedingChapter


Neuroprotective therapy is important not only for protecting neurons in the ischemic penumbra but also for protecting the neurovascular unit in the brain. Numerous potential agents have been studied for neuroprotection under ischemic conditions. However, only one free radical scavenger is currently available for clinical use in Japan. In this chapter, we discuss why many neuroprotective agents have failed to obtain clinical efficacy and what future studies should be focused on for achieving favorable results.

Original languageEnglish
Title of host publicationRational Basis for Clinical Translation in Stroke Therapy
PublisherCRC Press
Number of pages14
ISBN (Electronic)9781466594982
ISBN (Print)9781466594975
Publication statusPublished - 2014 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)
  • Chemistry(all)


Dive into the research topics of 'Neuroprotective Therapy: Failure and Future for Clinical Application'. Together they form a unique fingerprint.

Cite this