Cyclic ADP-ribose is generated from NAD+ in glucose-stimulated β-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.
- ADP-ribosyl cyclase
- cyclic ADP-ribose hydrolase