New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose

H. Okamoto; S. Takasawa; A. Tohgo

doi:10.1016/0300-9084(96)88146-6

New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose

H. Okamoto, S. Takasawa, A. Tohgo

HOSP - Surgery

Tohoku University

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Cyclic ADP-ribose is generated from NAD⁺ in glucose-stimulated β-cells by CD38. Cyclic ADP-ribose mobilizes Ca²⁺ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.

Original language	English
Pages (from-to)	356-363
Number of pages	8
Journal	Biochimie
Volume	77
Issue number	5
DOIs	https://doi.org/10.1016/0300-9084(96)88146-6
Publication status	Published - 1995

Keywords

ADP-ribosyl cyclase
CD38
cyclic ADP-ribose hydrolase
insulin

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10.1016/0300-9084(96)88146-6

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abstract = "Cyclic ADP-ribose is generated from NAD+ in glucose-stimulated β-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.",

keywords = "ADP-ribosyl cyclase, CD38, cyclic ADP-ribose hydrolase, insulin",

author = "H. Okamoto and S. Takasawa and A. Tohgo",

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AU - Okamoto, H.

AU - Takasawa, S.

AU - Tohgo, A.

PY - 1995

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AB - Cyclic ADP-ribose is generated from NAD+ in glucose-stimulated β-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.

KW - ADP-ribosyl cyclase

KW - CD38

KW - cyclic ADP-ribose hydrolase

KW - insulin

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ER -

New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose

Abstract

Keywords

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