New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

Osamu Yoshida, Jun Nakamura, Hidenori Yamashiro, Kenji Miura, Sayaka Hayashi, Kosei Umetsu, Shu Xu, Hideki Maki, Hirokazu Arimoto

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.

Original languageEnglish
Pages (from-to)278-282
Number of pages5
JournalMedChemComm
Volume2
Issue number4
DOIs
Publication statusPublished - 2011 Apr

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