New insights on T-cell self-tolerance

Jaeu Yi, Takeshi Kawabe, Jonathan Sprent

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Self-tolerance of T cells is maintained by a combination of thymic negative selection and suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC ligands. Treg function ensures that most T cells remain quiescent as naïve cells, but enables some T cells to proliferate and differentiate into cells with a memory phenotype (MP). In this review, we discuss how Tregs shape this compartmentalization of T cells into subsets of naïve and MP T cells.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalCurrent Opinion in Immunology
Publication statusPublished - 2020 Apr


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