Nickel-catalyzed cross-coupling of Grignard reagents with aryl (poly)fluorides or (poly)chlorides can be achieved efficiently in the presence of a new triarylphosphine ligand bearing a nearby hydroxy group. The high reactivity and the unique chemoselectivity (ArF > ArOTf ≫ ArSR) of the catalysis have been attributed to synergy of nickel and magnesium atoms preorganized on the ligand, as has been surmised on the basis of theoretical modeling of the reaction mechanism.
|Number of pages||2|
|Journal||Journal of the American Chemical Society|
|Publication status||Published - 2005 Dec 28|
ASJC Scopus subject areas
- Colloid and Surface Chemistry