TY - JOUR
T1 - No regional gray matter volume reduction observed in young Japanese people at ultra-high risk for psychosis
T2 - A voxel-based morphometry study
AU - Sakuma, Atsushi
AU - Obara, Chika
AU - Katsura, Masahiro
AU - Ito, Fumiaki
AU - Ohmuro, Noriyuki
AU - Iizuka, Kunio
AU - Kikuchi, Tatsuo
AU - Miyakoshi, Tetsuo
AU - Matsuoka, Hiroo
AU - Matsumoto, Kazunori
N1 - Funding Information:
This work was supported by The Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Grants-in-Aid for Scientific Research (KAKENHI) Grant Number 17790803 , 19591336 , 22390219 , 25461747 . The funder had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/10
Y1 - 2018/10
N2 - Objectives: Structural brain magnetic resonance imaging studies of individuals at ultra-high risk (UHR) for psychosis have shown subtle but widespread reductions in baseline gray matter volume (GMV) in the frontal, temporal, and limbic regions compared with healthy controls (HC). These regions coincide with regions of reduced GMV in patients with established psychosis and have led to the consideration of structural changes in UHR as a potential biomarker for future transition to psychosis. However, most studies have been from Europe, North America, and Australia, with few reports from other regions, and two recent studies from Asian countries have failed to detect regional GMV reduction in UHR, suggesting the need for further analysis of an Asian sample. In this study, we investigated GMV reduction in Japanese UHR subjects. Results: The study used voxel-based morphometry to compare magnetic resonance imaging brain scans between 45 UHR individuals recruited by a specialist and 33 HCs. This showed no significant GMV reduction in the UHR group compared with the healthy control group. This negative result may be attributable to characteristics of Asian samples, such as a low prevalence of illicit drug use, or to the heterogeneous nature of UHR subjects.
AB - Objectives: Structural brain magnetic resonance imaging studies of individuals at ultra-high risk (UHR) for psychosis have shown subtle but widespread reductions in baseline gray matter volume (GMV) in the frontal, temporal, and limbic regions compared with healthy controls (HC). These regions coincide with regions of reduced GMV in patients with established psychosis and have led to the consideration of structural changes in UHR as a potential biomarker for future transition to psychosis. However, most studies have been from Europe, North America, and Australia, with few reports from other regions, and two recent studies from Asian countries have failed to detect regional GMV reduction in UHR, suggesting the need for further analysis of an Asian sample. In this study, we investigated GMV reduction in Japanese UHR subjects. Results: The study used voxel-based morphometry to compare magnetic resonance imaging brain scans between 45 UHR individuals recruited by a specialist and 33 HCs. This showed no significant GMV reduction in the UHR group compared with the healthy control group. This negative result may be attributable to characteristics of Asian samples, such as a low prevalence of illicit drug use, or to the heterogeneous nature of UHR subjects.
KW - At-risk mental state
KW - Gray matter volume
KW - Magnetic resonance imaging
KW - Ultra-high risk for psychosis
KW - Voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=85054185856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054185856&partnerID=8YFLogxK
U2 - 10.1016/j.ajp.2018.09.009
DO - 10.1016/j.ajp.2018.09.009
M3 - Article
C2 - 30293050
AN - SCOPUS:85054185856
SN - 1876-2018
VL - 37
SP - 167
EP - 171
JO - Asian Journal of Psychiatry
JF - Asian Journal of Psychiatry
ER -
