Non-24-hour sleep–wake syndrome improved by low-dose valproic acid: A case report

Masatake Kurita, Takahiro Moriya, Satoshi Nishino, Eishin Hirata, Noriyasu Hirasawa, Yoshiro Okubo, Tadahiro Sato

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A woman was diagnosed with non-24-hour sleep–wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep–wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep–wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants. Low-dose valproic acid appears to be one of the effective means of entraining circadian rhythms in patients with non-24-hour sleep–wake syndrome, which in turn likely improves associated depressive symptoms.

Original languageEnglish
Pages (from-to)3199-3203
Number of pages5
JournalNeuropsychiatric Disease and Treatment
Publication statusPublished - 2016 Dec 13


  • Antidepressants
  • Circadian rhythm sleep disorder
  • Depression
  • Melatonin
  • Mood stabilizers
  • Phototherapy
  • Vitamin B12


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