Non-invasive estimation of human left ventricular end-diastolic pressure

Hideyuki Honda, Shigemitsu Nakaya, Hideichi Kamada, Hideyuki Hasegawa, Jun Demachi, Hisao Chikama, Koushirou Sugimura, Yoshito Yamamoto, Norihisa Kumasaka, Tamotsu Takita, Jun Ikeda, Hiroshi Kanai, Yoshiro Koiwa, Kunio Shirato

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Sato et al. (Electronic Letters 32, 949-950, 1996) reported that one can obtain a non-invasive estimate of left ventricular (LV) pressure at around end-diastole in an isolated canine preparation. In this study we examined whether this method can be applied to humans. Using the method proposed by Kanai et al. (IEEE. Trans. UFFC, 43, 791-810,1996), we detected small amplitude LV vibration from an ultrasonic pulse Doppler signal reflected from the interventricular septum in five patients (44-63 y.o., male;4, female;l). We measured the oscillation frequency of the LV wall through the wavelet transform of small amplitude LV vibration, and calculated LV pressure at around end-diastole from the values of oscillation frequency, internal radius and wall thickness using Mirsky's equation. The estimated LV pressures at around end-diastole were similar to end-diastolic pressure measured directly by cardiac catheterization. These results show the possibility that this method allows for the non-invasive estimate of LV pressure at around end-diastole, and furthermore provides the basis for future clinical applicability of this technique.

Original languageEnglish
Pages (from-to)485-488
Number of pages4
JournalMedical Engineering and Physics
Issue number6
Publication statusPublished - 1998 Sept


  • End-diastolic pressure
  • Left ventricle
  • Myocardial elasticity


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