Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage

Shuzo Yamamoto; Tatsushi Mutoh; Kazumasu Sasaki; Tomoko Mutoh; Yasuko Tatewaki; Yasuyuki Taki

doi:10.1111/1440-1681.13035

Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage

Shuzo Yamamoto, Tatsushi Mutoh, Kazumasu Sasaki, Tomoko Mutoh, Yasuko Tatewaki, Yasuyuki Taki

Tohoku University

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

We aimed to evaluate the feasibility of a non-invasive method of cerebral blood flow (CBF) measurement using high-frequency power Doppler ultrasound imaging in a mouse model of subarachnoid haemorrhage (SAH). The 3-dimensionally (3D) reconstructed blood flow signals (%vascularity) within the brain volume of the middle cerebral artery territory correlated well with reference parameters, baseline carotid artery blood flow (r²= 0.52, P < 0.0001) and normalized CBF changes (r²= 0.74 P < 0.0001). These data suggest that the 3D power Doppler analysis may have the potential for reflecting real-time CBF changes during the acute phase of experimental SAH, which may be applicable to preclinical studies on early brain injury.

Original language	English
Pages (from-to)	99-102
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	46
Issue number	1
DOIs	https://doi.org/10.1111/1440-1681.13035
Publication status	Published - 2019 Jan

Keywords

cerebral blood flow
mouse model
subarachnoid haemorrhage
ultrasound imaging

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10.1111/1440-1681.13035

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abstract = "We aimed to evaluate the feasibility of a non-invasive method of cerebral blood flow (CBF) measurement using high-frequency power Doppler ultrasound imaging in a mouse model of subarachnoid haemorrhage (SAH). The 3-dimensionally (3D) reconstructed blood flow signals (%vascularity) within the brain volume of the middle cerebral artery territory correlated well with reference parameters, baseline carotid artery blood flow (r2= 0.52, P < 0.0001) and normalized CBF changes (r2= 0.74 P < 0.0001). These data suggest that the 3D power Doppler analysis may have the potential for reflecting real-time CBF changes during the acute phase of experimental SAH, which may be applicable to preclinical studies on early brain injury.",

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language = "English",

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Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage. / Yamamoto, Shuzo; Mutoh, Tatsushi; Sasaki, Kazumasu et al.
In: Clinical and Experimental Pharmacology and Physiology, Vol. 46, No. 1, 01.2019, p. 99-102.

Research output: Contribution to journal › Letter › peer-review

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AU - Mutoh, Tomoko

AU - Tatewaki, Yasuko

AU - Taki, Yasuyuki

N1 - Funding Information: Grants‐in‐Aid for Scientific Research from Japan Society for the Promotion of Science/ Grant Numbers: 17K11563, 18K08880. Publisher Copyright: © 2018 John Wiley & Sons Australia, Ltd

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Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage

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