TY - JOUR
T1 - Nonapoptotic functions of caspases
T2 - caspases as regulatory molecules for immunity and cell-fate determination
AU - Kuranaga, Erina
AU - Miura, Masayuki
N1 - Funding Information:
We apologize to colleagues whose work could not be cited owing to space limitations. This work was supported in part by grants from the Suzuken Memorial Foundation, the Takeda Science Foundation, Kanae Foundation and Life Science Foundation of Japan to E.K. This work was also supported in part by grants from the Japanese Ministry of Education, Science, Sports, Culture and Technology to E.K. and M.M. In addition, this work was supported in part by a RIKEN Bioarchitect Research Grant, the TORAY Science Foundation, The Cell Science Research Foundation, Naito Foundation and the Astellas Foundation for Research on Metabolic Disorders to M.M.
PY - 2007/3
Y1 - 2007/3
N2 - Caspases are a family of cysteine proteases that are highly conserved in multicellular organisms and function as central regulators of apoptosis. Recent investigations in Caenorhabditis elegans, Drosophila and mice suggest that caspases also function as regulatory molecules for immunity and cell-fate determination. Here, we review genetic studies of nonapoptotic functions of caspases and discuss the regulatory mechanisms of caspases for executing nonapoptotic functions.
AB - Caspases are a family of cysteine proteases that are highly conserved in multicellular organisms and function as central regulators of apoptosis. Recent investigations in Caenorhabditis elegans, Drosophila and mice suggest that caspases also function as regulatory molecules for immunity and cell-fate determination. Here, we review genetic studies of nonapoptotic functions of caspases and discuss the regulatory mechanisms of caspases for executing nonapoptotic functions.
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U2 - 10.1016/j.tcb.2007.01.001
DO - 10.1016/j.tcb.2007.01.001
M3 - Review article
C2 - 17275304
AN - SCOPUS:33847367323
SN - 0962-8924
VL - 17
SP - 135
EP - 144
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 3
ER -