TY - JOUR
T1 - Noninvasive quantification of rCBF using positron emission tomography
AU - Watabe, H.
AU - Itoh, M.
AU - Cunningham, V.
AU - Lammertsma, A. A.
AU - Bloomfield, P.
AU - Mejia, M.
AU - Fujiwara, T.
AU - Jones, A. K.P.
AU - Jones, T.
AU - Nakamura, T.
PY - 1996
Y1 - 1996
N2 - This study proposes a new method for the pixel-by-pixel quantification of regional CBF (rCBF) with positron emission tomography and H2/15O by using a reference tissue region. No arterial blood is required. Simulation studies revealed that the calculation of rCBF was fairly stable provided that the frame time was relatively short compared with total scan time. In practice, calculated CBF images correlated significantly with those obtained with the dynamic/integral method. Because the method accurately detects changes in CBF, it is particularly suitable for brain activation studies.
AB - This study proposes a new method for the pixel-by-pixel quantification of regional CBF (rCBF) with positron emission tomography and H2/15O by using a reference tissue region. No arterial blood is required. Simulation studies revealed that the calculation of rCBF was fairly stable provided that the frame time was relatively short compared with total scan time. In practice, calculated CBF images correlated significantly with those obtained with the dynamic/integral method. Because the method accurately detects changes in CBF, it is particularly suitable for brain activation studies.
KW - Noninvasive quantification
KW - Positron emission tomography
KW - Regional cerebral blood flow
UR - http://www.scopus.com/inward/record.url?scp=9044230120&partnerID=8YFLogxK
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U2 - 10.1097/00004647-199603000-00017
DO - 10.1097/00004647-199603000-00017
M3 - Article
C2 - 8594064
AN - SCOPUS:9044230120
SN - 0271-678X
VL - 16
SP - 311
EP - 319
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 2
ER -