TY - JOUR
T1 - Normal CBF values by the ARG method using IMP SPECT
T2 - Comparison with a conventional microsphere model method
AU - Ito, Hiroshi
AU - Ishii, Kiyoshi
AU - Kinoshita, Toshifumi
AU - Koyama, Masamichi
AU - Kawashima, Ryuta
AU - Ono, Shuichi
AU - Fukuda, Hiroshi
N1 - Funding Information:
We thank Dr Paul F. Cranefield for constant encouragement, and Diane Schenkman and Peter Hoff for technical assistance. This work was supported by National Institutes of Health Grants HL-14899 and HL-36783 and by the American Heart Association, New York City Affiliate. D.C.G. is a Career Scientist of the Irma T. Hirschl Trust.
PY - 1996
Y1 - 1996
N2 - N-isopropyl-p[ 123I]iodoamphetamine (IMP) has been used as a flow tracer for SPECT, and measurement of cerebral blood flow (CBF) using IMP has been performed by conventional microsphere model method (MS method). Recently, the ARG method for measuring CBF by using IMP with one SPECT scan and one point blood sampling has been developed. This method was based on two-compartment model. In the present study, normal CBF values were measured in ten male healthy subjects (mean age ± S.D.: 29.8±6.01, age range: 23- 41) by the ARG and the MS methods. The mean CBF values (±S.D.) for the ARG method in which the V(d) value was assumed to be 50 ml/ml were 41.7±9.4, 31.1±5.0, 40.7±9.7, 41.5 ±10.0, 38.2±9.2, 39.0±9.4, 41.9±10.6, 38.7±8.0 and 30.0±7.7 ml/100 ml/min in the cerebellum, pons, thalamus, basal ganglia, frontal, temporal, parietal, occipital lobe cortex and centrum semiovale, respectively. The mean CBF values for the MS method were 46.8±8.4, 37.5±5.6, 45.8±8.6, 46.5±8.9, 43.7± 8.3, 44.4±8.7, 46.8±9.3, 44.3±7.3 and 36.3±8.1 ml/100 ml/min, respectively. The mean CBF values in the cerebral cortex region for the ARG method were lower than those previously reported by PET. This would be caused by low first-pass extraction fraction of IMP compared with oxygen-15 labeled water. The mean CBF values for the MS method were higher than those for the ARG method against previous studies. As reasons for this, errors in estimation of the SPECT brain counts at 8 min in the MS method were considered.
AB - N-isopropyl-p[ 123I]iodoamphetamine (IMP) has been used as a flow tracer for SPECT, and measurement of cerebral blood flow (CBF) using IMP has been performed by conventional microsphere model method (MS method). Recently, the ARG method for measuring CBF by using IMP with one SPECT scan and one point blood sampling has been developed. This method was based on two-compartment model. In the present study, normal CBF values were measured in ten male healthy subjects (mean age ± S.D.: 29.8±6.01, age range: 23- 41) by the ARG and the MS methods. The mean CBF values (±S.D.) for the ARG method in which the V(d) value was assumed to be 50 ml/ml were 41.7±9.4, 31.1±5.0, 40.7±9.7, 41.5 ±10.0, 38.2±9.2, 39.0±9.4, 41.9±10.6, 38.7±8.0 and 30.0±7.7 ml/100 ml/min in the cerebellum, pons, thalamus, basal ganglia, frontal, temporal, parietal, occipital lobe cortex and centrum semiovale, respectively. The mean CBF values for the MS method were 46.8±8.4, 37.5±5.6, 45.8±8.6, 46.5±8.9, 43.7± 8.3, 44.4±8.7, 46.8±9.3, 44.3±7.3 and 36.3±8.1 ml/100 ml/min, respectively. The mean CBF values in the cerebral cortex region for the ARG method were lower than those previously reported by PET. This would be caused by low first-pass extraction fraction of IMP compared with oxygen-15 labeled water. The mean CBF values for the MS method were higher than those for the ARG method against previous studies. As reasons for this, errors in estimation of the SPECT brain counts at 8 min in the MS method were considered.
KW - ARG method
KW - CBF
KW - IMP
KW - Normal value
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M3 - Article
C2 - 8721106
AN - SCOPUS:0029869453
SN - 0022-7854
VL - 33
SP - 175
EP - 178
JO - Kaku igaku. The Japanese journal of nuclear medicine
JF - Kaku igaku. The Japanese journal of nuclear medicine
IS - 2
ER -