Normal cerebral perfusion of99mTc-ECD brain SPECT - Evaluation by an anatomical standardization technique

Ryuta Kawashima; Masamichi Koyama; Hiroshi Ito; Seiro Yoshioka; Kazunori Sato; Shuichi Ono; Ryoui Goto; Tachio Sato; Hiroshi Fukuda

Normal cerebral perfusion of^99mTc-ECD brain SPECT - Evaluation by an anatomical standardization technique

Ryuta Kawashima, Masamichi Koyama, Hiroshi Ito, Seiro Yoshioka, Kazunori Sato, Shuichi Ono, Ryoui Goto, Tachio Sato, Hiroshi Fukuda

Division of Brain Science

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A single photon emitter labeled tracer, ^99mTc-ethyl cysteinate dimer (^99mTc-ECD), has now been used for rCBF studies with SPECT. However, normal distribution pattern of this agent in the brain still remains unclear. Therefore, the specific purpose of this study was to investigate the normal distribution pattern of ^99mTcECD SPECT image. Regional cerebral distribution was measured with SPECT and 984±17 MBq of ^99mTc-ECD in ten normal subjects. During the SPECT measurement, subjects were placed comfortably in a supine position with their eyes closed. Each SPECT image was anatomically standardized using a computerized brain at-las system of Roland et al. (HBA: Human Brain Atlas) and X-CT image. Anatomically standardized SPECT images were globally normalized to 100 count/voxel. Then, the mean and SD images of brain SPECT were calculated voxel-by-voxel basis. The highest radioactivity was found in the medial aspect of the occipital lobe. The results indicate that the normal distribution pattern of ^99mTc-ECD in the human brain may be not simply reflect the regional cerebral blood flow.

Original language	English
Pages (from-to)	69-72
Number of pages	4
Journal	Kakuigaku
Volume	33
Issue number	1
Publication status	Published - 1996 Dec 1

Keywords

Anatomical standardization
Cerebral perfusion
Human brain
SPECT
Tc-ECD

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Normal cerebral perfusion of99mTc-ECD brain SPECT - Evaluation by an anatomical standardization technique",

abstract = "A single photon emitter labeled tracer, 99mTc-ethyl cysteinate dimer (99mTc-ECD), has now been used for rCBF studies with SPECT. However, normal distribution pattern of this agent in the brain still remains unclear. Therefore, the specific purpose of this study was to investigate the normal distribution pattern of 99mTcECD SPECT image. Regional cerebral distribution was measured with SPECT and 984±17 MBq of 99mTc-ECD in ten normal subjects. During the SPECT measurement, subjects were placed comfortably in a supine position with their eyes closed. Each SPECT image was anatomically standardized using a computerized brain at-las system of Roland et al. (HBA: Human Brain Atlas) and X-CT image. Anatomically standardized SPECT images were globally normalized to 100 count/voxel. Then, the mean and SD images of brain SPECT were calculated voxel-by-voxel basis. The highest radioactivity was found in the medial aspect of the occipital lobe. The results indicate that the normal distribution pattern of 99mTc-ECD in the human brain may be not simply reflect the regional cerebral blood flow.",

keywords = "Anatomical standardization, Cerebral perfusion, Human brain, SPECT, Tc-ECD",

author = "Ryuta Kawashima and Masamichi Koyama and Hiroshi Ito and Seiro Yoshioka and Kazunori Sato and Shuichi Ono and Ryoui Goto and Tachio Sato and Hiroshi Fukuda",

year = "1996",

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journal = "Kakuigaku",

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T1 - Normal cerebral perfusion of99mTc-ECD brain SPECT - Evaluation by an anatomical standardization technique

AU - Kawashima, Ryuta

AU - Koyama, Masamichi

AU - Ito, Hiroshi

AU - Yoshioka, Seiro

AU - Sato, Kazunori

AU - Ono, Shuichi

AU - Goto, Ryoui

AU - Sato, Tachio

AU - Fukuda, Hiroshi

PY - 1996/12/1

Y1 - 1996/12/1

N2 - A single photon emitter labeled tracer, 99mTc-ethyl cysteinate dimer (99mTc-ECD), has now been used for rCBF studies with SPECT. However, normal distribution pattern of this agent in the brain still remains unclear. Therefore, the specific purpose of this study was to investigate the normal distribution pattern of 99mTcECD SPECT image. Regional cerebral distribution was measured with SPECT and 984±17 MBq of 99mTc-ECD in ten normal subjects. During the SPECT measurement, subjects were placed comfortably in a supine position with their eyes closed. Each SPECT image was anatomically standardized using a computerized brain at-las system of Roland et al. (HBA: Human Brain Atlas) and X-CT image. Anatomically standardized SPECT images were globally normalized to 100 count/voxel. Then, the mean and SD images of brain SPECT were calculated voxel-by-voxel basis. The highest radioactivity was found in the medial aspect of the occipital lobe. The results indicate that the normal distribution pattern of 99mTc-ECD in the human brain may be not simply reflect the regional cerebral blood flow.

AB - A single photon emitter labeled tracer, 99mTc-ethyl cysteinate dimer (99mTc-ECD), has now been used for rCBF studies with SPECT. However, normal distribution pattern of this agent in the brain still remains unclear. Therefore, the specific purpose of this study was to investigate the normal distribution pattern of 99mTcECD SPECT image. Regional cerebral distribution was measured with SPECT and 984±17 MBq of 99mTc-ECD in ten normal subjects. During the SPECT measurement, subjects were placed comfortably in a supine position with their eyes closed. Each SPECT image was anatomically standardized using a computerized brain at-las system of Roland et al. (HBA: Human Brain Atlas) and X-CT image. Anatomically standardized SPECT images were globally normalized to 100 count/voxel. Then, the mean and SD images of brain SPECT were calculated voxel-by-voxel basis. The highest radioactivity was found in the medial aspect of the occipital lobe. The results indicate that the normal distribution pattern of 99mTc-ECD in the human brain may be not simply reflect the regional cerebral blood flow.

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KW - Tc-ECD

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