@article{6603ef0fd1c944c0a61703a03614db73,
title = "Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7",
abstract = "Sleep is found widely in the animal kingdom. Despite this, few conserved molecular pathways that govern sleep across phyla have been described. The mammalian brain-type fatty acid binding protein (Fabp7) is expressed in astrocytes, and its mRNA oscillates in tandem with the sleep-wake cycle. However, the role of FABP7 in regulating sleep remains poorly understood. We found that the missense mutation FABP7.T61M is associated with fragmented sleep in humans. This phenotype was recapitulated in mice and fruitflies bearing similar mutations: Fabp7-deficient mice and transgenic flies that express the FABP7.T61M missense mutation in astrocytes also show fragmented sleep. These results provide novel evidence for a distinct molecular pathway linking lipid-signaling cascades within astrocytes in sleep regulation among phylogenetically disparate species.",
author = "Gerstner, {Jason R.} and Perron, {Isaac J.} and Riedy, {Samantha M.} and Takeo Yoshikawa and Hiroshi Kadotani and Yuji Owada and {Van Dongen}, {Hans P.A.} and Galante, {Raymond J.} and Kaitlin Dickinson and Yin, {Jerry C.P.} and Pack, {Allan I.} and Frank, {Marcos G.}",
note = "Funding Information: We thank R. Taylor, J. Lian, and L. Zhang for technical assistance and helpful advice. We also thank M. Freeman for the Alrm-Gal4 Drosophila driver lines, A. Sehgal and J. Krueger for insightful discussions and editing of the manuscript, and K. Yamamoto and H. Okamura for genome-wide association analysis. Funding: This work was supported by NIH grants HL007713, HL111725, and MH099544; by Office of Naval Research grant N00014-13-1-0302; and by Ministry of Education, Culture, Sports, Science and Technology KAKENHI 221S0002. T.Y. was funded by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and Development. Publisher Copyright: 2017 {\textcopyright} The Authors.",
year = "2017",
month = apr,
doi = "10.1126/sciadv.1602663",
language = "English",
volume = "3",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "4",
}