Notch signaling in induced pluripotent stem cells

Thanaphum Osathanon, Hiroshi Egusa

Research output: Chapter in Book/Report/Conference proceedingChapter


Notch signaling is a conserved pathway among species ranging from fruit flies to mammals. Notch is a unique pathway that required direct cell-to-cell contact in order to activate intracellular signaling. Binding of Notch receptors to ligands results in the release of Notch intracellular domain from the transmembrane domain. Notch intracellular domain then further translocates into the nucleus and forms complex with other factors, leading to target gene activation. Notch controls stem cell behavior in cell type and stage-specific manner. Modulation of Notch signaling affects the generation efficacy, stemness maintenance, and specific lineage differentiation of induced pluripotent stem cells. This chapter reviews the basic knowledge of Notch signaling, the effect of Notch signaling in stemness maintenance and differentiation. Role of Notch signaling in induced pluripotent stem cells is also described.

Original languageEnglish
Title of host publicationMolecular Players in iPSC Technology
Number of pages36
ISBN (Electronic)9780323900591
Publication statusPublished - 2021 Jan 1


  • Adipogenic
  • Canonical pathway
  • Differentiation
  • Embryonic stem cells
  • Induced pluripotent stem cells
  • Intracellular signaling
  • Ligand
  • Mesenchymal stem cells
  • Neurogenic
  • Notch
  • Osteogenic
  • Pluripotency
  • Proliferation
  • Receptor
  • Stemness

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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