@article{bb18c8f39cd043e7ad15f6cc398081ab,
title = "Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates",
abstract = "Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel γ-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arranged on the core six-membered ring. Structure-activity relationship studies of these compounds were also developed.",
keywords = "γ-Secretase, Cyclohexenone, Inhibitor, Structure-activity relationships",
author = "Yasuko Takahashi and Haruhiko Fuwa and Akane Kaneko and Makoto Sasaki and Satoshi Yokoshima and Hifumi Koizumi and Tohru Takebe and Toshiyuki Kan and Takeshi Iwatsubo and Taisuke Tomita and Hideaki Natsugari and Tohru Fukuyama",
note = "Funding Information: This work was financially supported in part by a Grant for the 21st Century COE Program and Scientific Research on Priority Areas from The Ministry of Education, Culture, Sports, Science and Technology (MEXT) and by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO), Japan. Y.T. and H.F. are a research fellow and a postdoctoral fellow, respectively, of Japan Society for the Promotion of Science (JSPS).",
year = "2006",
month = jul,
day = "15",
doi = "10.1016/j.bmcl.2006.04.025",
language = "English",
volume = "16",
pages = "3813--3816",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "14",
}