Multiply substituted tetrahydrofuran rings can be prepared by the [3+2] cycloaddition of alkylidenecyclopropanes 1 with aldehydes 2 [Eq. (1)]. In this reaction, the distal bond of the cyclopropane ring is cleaved, and 3-methylenetetrahydrofuran derivatives 3 are produced in good yields.
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2001 Apr 2|
- Cycloaddition heterocycles
- Synthetic methods