Novel concepts for organic syntheses based on interfaces and molecular machines

Shinsuke Ishihara, Yutaka Wakayama, Nobuya Hiroshiba, Jonathan P. Hill, Katsuhiko Ariga

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    Without doubt, organic chemistry has made significant contributions in improving the qualities of our lives. However, there exists a demand for well-designed molecules of complex structures with additional requirements for low-cost and low-energy production of the materials, which stimulate us to consider innovative concepts in organic synthetic methods. In order to propose innovative methods for next-generation organic synthetic procedures, we present two strategies, (i) organic synthesis within two-dimensional molecular patterns and (ii) organic synthesis driven by molecular machines working at interfaces. For example, synthesis of stereo-regulated polymeric materials in two-dimensional molecular arrays, tip-induced chemical reactions at a solid surface, sequential reactions guided by polymer chains, DNA-nanorobots on two-dimensional DNA origami, ester hydrolysis based on modified behavior of protonated amines at an interface, and several other methods are introduced as pioneering and innovative concepts.

    Original languageEnglish
    Pages (from-to)428-438
    Number of pages11
    JournalCurrent Organic Synthesis
    Issue number4
    Publication statusPublished - 2012 Aug 9


    • DNA Origami
    • Interface
    • Molecular Machine
    • Molecular Pattern
    • Molecular Recognition
    • Surface

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry


    Dive into the research topics of 'Novel concepts for organic syntheses based on interfaces and molecular machines'. Together they form a unique fingerprint.

    Cite this