TY - JOUR
T1 - Nuclear actin activates human transcription factor genes including the OCT4 Gene
AU - Yamazaki, Shota
AU - Yamamoto, Koji
AU - Tokunaga, Makio
AU - Sakata-Sogawa, Kumiko
AU - Harata, Masahiko
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research on Innovative Areas to M.T., K.S-S., and M.H., and by the Human Frontier Science Program (RGP0017) to M.H. S.K. was supported by Grant-in-Aid for JSPS Fellows.
Publisher Copyright:
© 2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
PY - 2015
Y1 - 2015
N2 - RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. Oct4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types and could be used for gene reprogramming of human cells.
AB - RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. Oct4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types and could be used for gene reprogramming of human cells.
KW - Nuclear actin
KW - OCT4
KW - Transcription
KW - Transcription microarray
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U2 - 10.1080/09168451.2014.972332
DO - 10.1080/09168451.2014.972332
M3 - Article
C2 - 25355676
AN - SCOPUS:84929414168
SN - 0916-8451
VL - 79
SP - 242
EP - 246
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 2
ER -