Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat

Mikio Nishizawa; Yumiko Hayakawa; Noboru Yanaihara; Hiroshi Okamoto

doi:10.1016/0014-5793(85)80953-4

Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat

Mikio Nishizawa, Yumiko Hayakawa, Noboru Yanaihara, Hiroshi Okamoto

HOSP - Surgery

Research output: Contribution to journal › Article › peer-review

203 Citations (Scopus)

Abstract

The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology. Rat VIP Rat PHI-27 VIP precursor VIP precursor mRNA Human PHM-27 Sequence homology.

Original language	English
Pages (from-to)	55-59
Number of pages	5
Journal	FEBS Letters
Volume	183
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(85)80953-4
Publication status	Published - 1985 Apr 8

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title = "Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat",

abstract = "The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology. Rat VIP Rat PHI-27 VIP precursor VIP precursor mRNA Human PHM-27 Sequence homology.",

author = "Mikio Nishizawa and Yumiko Hayakawa and Noboru Yanaihara and Hiroshi Okamoto",

note = "Funding Information: This work was supportedi n part by Grants-in-Aid for Scientific Research and for Cancer Researchf rom the Ministry of Education, Science and Culture, Japan.",

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AU - Nishizawa, Mikio

AU - Hayakawa, Yumiko

AU - Yanaihara, Noboru

AU - Okamoto, Hiroshi

N1 - Funding Information: This work was supportedi n part by Grants-in-Aid for Scientific Research and for Cancer Researchf rom the Ministry of Education, Science and Culture, Japan.

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N2 - The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology. Rat VIP Rat PHI-27 VIP precursor VIP precursor mRNA Human PHM-27 Sequence homology.

AB - The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology. Rat VIP Rat PHI-27 VIP precursor VIP precursor mRNA Human PHM-27 Sequence homology.

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Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat

Abstract

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