Numerical analysis of one-dimensional mathematical model of blood flow to reproduce fundamental pulse wave measurement for scientific verification of pulse diagnosis

Pulse diagnosis in traditional Chinese medicine is said to be able to detect not only illness but also decline of health in the patients from tactile sense of the pulse in the radial artery at the wrists. This diagnosis, however, is not supported by concrete scientific evidence. The authors have proposed a non-linear spring model of subcutaneous tissue on the radial artery and one-dimensional arterial blood flow model in an arm for the purpose of scientific verification of the pulse diagnosis. They performed, in the former study, a numerical experiment with this mathematical model in which the radial artery was indented in a stepwise manner by a pressure sensor, which extract the fundamental mechanism of the pulse diagnosis, to validate the subcutaneous tissue model and to find the appropriate coefficient to fit the experimental result. They investigated, in this research, contribution of parameters of supply pressure of the blood and tube law of the artery on the change in the pressure pulse waves with the indentation steps with respect to mean value P _oav and amplitude ΔP _o of the pressure. It was shown that mean supply pressure affects both P _oav and ΔP _o, while amplitude of the supply pressure affects ΔP _o. It was also shown that profile of ΔP _o vs. distance of the indentation changes drastically as the artery becomes hard. Lastly, it was examined to reproduce the experimentally obtained pressure pulse waves during the indentation in their former work with the mathematical model by adjusting the parameters. The result showed better agreement than the former result, but it implied that ulnar artery had to be taken into consideration for quantitative fitting of the pulse waves to the range where the radial artery was nearly flattened by the indentation.