The purpose of this paper is to present a numerical evaluation method for the aerodynamic design and development of high-efficiency exhaust diffusers in steam turbines, as well as to present the comparison between the numerical results and measured data in an actual real scale development steam turbine. This paper presents numerical investigation of three-dimensional wet steam flows in a down-flow-type exhaust diffuser that has non-uniform inlet flows from a typical last turbine stage. This stage has long transonic blades designed using recent aerodynamic and mechanical design technologies, including superimposed leakages and blade wakes from several upstream low pressure turbine stages. The present numerical flow analysis showed detail three-dimensional flow structures considering circumferential flow distributions caused by the down-flow exhaust hood geometry and the swirl velocity component from the last stage blades, including flow separations in the exhaust diffuser. The results were compared with experimental data measured in an actual development steam turbine. Consequently, the proposed aerodynamic evaluation method was proved to be sufficiently accurate for steam turbine exhaust diffuser aerodynamic designs.